From New Jersey on I-295 or the New Jersey Turnpike:

Option A: (Shortest) Take US 322 West (Exit 2 from NJTP). Proceed west and cross the Delaware River on the Commodore Barry Bridge. Follow signs leading to I-95 South, then follow the directions below, From the North on I-95.

Option B: Go to the end on the NJTP and cross the Delaware Memorial Bridge. After leaving the bridge, follow signs and get on I-95 North. Go through Wilmington and take Exit 8, US 202 North. After getting on 202 North, get into the far left lane and go 0.9 miles to Rt 141. Turn left onto Rt. 141 South and go 2.4 miles to a traffic light at the top of a long hill. Get into the left turn lane and turn left at the traffic light. Go 350 ft., then turn right on Old Church Road at the church sign.

From the North on I-95:

Take Exit 8, US 202 North. After getting on 202 North, get into the far left lane and go 0.9 miles to Rt. 141. Turn left on Rt. 141 South and go 2.4 miles to a traffic light at the top of a long hill. Get into the left turn lane and turn left at the traffic light. Go 350 ft., then turn right on Old Church Road at the church sign.

From the North on US 202:

Nearing Wilmington, look for a single high rise office building on the right. Go past this building 0.3 mile, then turn right onto Rt. 141 South. Go 2.4 miles on Rt 141 South to a traffic light at the top of a long hill. Get into the left turn lane and turn left at the traffic light. Go 350 ft., and turn right on Old Church Road at the church sign.

From the South on I-95:

Take Exit 5B to Rt. 141 North (Newport Exit). Go 6.1 miles on Rt. 141 North to an intersection at a traffic light. As you approach this intersection you will pass under a railroad bridge and a highway bridge. Get in the right lane and turn right at the traffic light. Go 300 ft., then turn right again onto Old Church Road at the church sign.

From the West on PA / DE Route 41:

Go through Avondale, PA and Hockessin, DE. 1.3 miles after the last traffic light in Hockessin, angle left at a traffic light onto Rt. 48 East. Go 4 miles on Rt. 48, then turn left at a major intersection onto Rt. 141 North. Proceed 1.4 miles to an intersection at a traffic light. As you approach this intersection you will pass under a railroad bridge and a highway bridge. Get in the right lane and turn right at the traffic light. Go 300 ft., then turn right again onto Old Church Road at the church sign.

Click on the link below to show a map of the area:

Map of St. Joseph on the Brandywine, 10 Old Church Rd
Wilmington, DE 19807-3046